Small but significant levels of PFC have been detected in blood samples from animals either ventilated with PFC liquid or after intratracheal instillation of PFC liquids.
.Across studies, PFC concentration in the blood ranged from 0.25 μg to10 μg PFC per milliliter of blood and reached a plateau by 15 to 120 minutes of liquid ventilation, depending on the physical properties of the PFC liquid, the technique of PFC administration, and the species or animal preparation studied.
The concentration of PFC in the tissues with liquid ventilation is organ dependent, with the highest PFC level typically found in the lungs. In contrast to amounts found in the lungs, there were smaller amounts of PFC reported in other organs. The lowest levels were typically found in organs with low lipid content, and the highest were found in organs with high lipid content. As noted by several investigators after return to gas ventilation, there was an overall reduction in PFC levels in organs as a function of gas ventilation duration. This reduction in PFC concentration in tissue was paralleled by a decrease in PFC vapor in expired gas as a function of time after return to gas ventilation.
Shaffer, T.H. and M.R. Wolfson, Liquid Ventilation, in Fetal and Neontal Physiology, R.A. Polin, W.W. Fox, and S.H. Abman, Editors. 2011, Elsevier: Philadelphia, PA. p.1063.
Neonatal Liquid Ventilation